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Genomic Biomarkers For Risk Stratification In Prostate Cancer
MONTEREY, CA, USA (UroToday.com) - In his State-of-the-Art talk, Colin Collins discussed biomarkers for prostate cancer (CaP) risk stratification. He asked where genome copy number profiles can predict CaP recurrences. To explore this, his group used array comparative genomic hybridization (CGH) to identify genes mutations. The array data displays gene amplification and losses as topographical data.
Robot Assisted Radical Cystectomy: Is It Ready For Prime Time?
MONTEREY, CA, USA (UroToday.com) - A State-of-the-Art lecture by Erik Castle addressed the question of whether robotic cystectomy was ready for “prime time.” Prime time was defined as an operation that is equivalent to open surgery, reasonable, reproducible, and teachable. Is it equivalent to open cystectomy? He discussed the oncologic outcome of lymph node count, which improved with experience in his series from 11 in the first 10 cases to 21 in the last 10 cases.
Targeted Therapies In Prostate And Renal Cancers
MONTEREY, CA, USA (UroToday.com) - In this session, Christopher P. Evans presented a State-of-the-Art lecture on molecular targets in prostate and renal cancers. Molecular targets in cancer diagnosis and therapy have come to the fore of the oncology field in the last decade. Their identification is rooted in basic science investigation and enhanced knowledge in the fields of genetics, biochemistry, molecular and tumor biology, and pathology, among others.
Sibling Study Could Lead To Better Treatments For Inherited Form Of Colon Cancer - Huntsman Cancer Institute
Researchers at Huntsman Cancer Institute (HCI) believe they may be one step closer to understanding how certain forms of colon cancer develop. In a study using siblings who have been diagnosed with colon cancer, scientists discovered similarities on a region of a particular chromosome, referred to as 7q31. Researchers believe that piece of genetic material may be causing a subset of colon cancers that run in families.
Early Versus Delayed Endocrine Treatment Of T2-T3 PN1-3 M0 Prostate Cancer Without Local Treatment Of The Primary Tumour
UroToday.com - Protocol 30846 of the EORTC-GU Group recruited 234 patients with histologically proven lymph node positive disease (pN1-3) according to the TNM classification of 1992. This included regional but not para-aortic lymph node disease. At the time the study was initiated in 1983, lymph node positive disease was encountered in 20 to 50% of cases that were clinically considered to be eligible for radical prostatectomy or radiotherapy.
Randomized Phase II Trial Evaluation Of Erectile Function After Attempted Unilateral Cavernous Nerve-Sparing Retropubic Radical Prostatectomy
UroToday.com - In 1999, Kim et al. from Baylor College of Medicine reported promising potency results from bilateral interposition of sural nerve grafts after bilateral non nerve sparing radical prostatectomy (RP). Our institution was able to duplicate these findings in the bilateral graft model as well. However, we were not sure how to properly analyze the efficacy of a unilateral nerve sparing plus unilateral non-nerve sparing with and without a unilateral sural nerve graft.
Saturation Biopsies On Autopsied Prostates For Detecting And Characterizing Prostate Cancer
UroToday.com - This paper reports the results of a saturation biopsy protocol of 36 cores performed on 48 autopsied prostates from deceased men without any past history of prostate cancer. The first 18 cores were taken in the mid peripheral zone (6 cores), the lateral peripheral zone (6 cores) and the central zone (6 cores). An additional set of 18 cores were taken in the same locations, bringing the total number of cores to 36. Autopsied glands were then step-sectioned and analysed.
Cells With Extra Chromosomes Share Detrimental Traits That Might Help Develop Cancer Treatments
Mammalian cells with extra chromosomes share some common traits that could be exploited to develop cancer treatments, according to MIT biologists. Having too many chromosomes, a condition known as aneuploidy, wreaks havoc on an organism, usually resulting in birth defects or death. However, it seems to confer an advantage on tumor cells, which are nearly always aneuploid.
National Grants Further WA Medical Research In Australia
National grants totalling more than $6 million dollars have been awarded to the State’s premier medical research facility, the Western Australian Institute for Medical Research (WAIMR), in support of a range of ground-breaking, world-first research projects.
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