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CHEST 2008: New Pulmonary Hypertension Research Presented

#6363 TADALAFIL PROVES EFFECTIVE THERAPY FOR PULMONARY HYPERTENSION New research shows that the erectile dysfunction drug, tadalafil, may be an effective adjunct therapy for patients with pulmonary arterial hypertension (PAH). Italian researchers randomized 405 patients with PAH, of whom 53 percent were taking concomitant bosentan, to two study arms. The groups received either tadalafil or placebo orally once daily as monotherapy or as add-on therapy to bosentan.

Link Found Between Obesity And Erectile Dysfunction

A new study states that obese men with erectile dysfunction (ED) are shown to have low levels of hormones, such as testosterone. The findings also show that certain conditions associated with obesity, particularly hypertension, are the most important determinants of obesity-related ED. The study was published in The Journal of Sexual Medicine, the official journal of the International Society for Sexual Medicine.

Menopause Can Be Predicted Within A Year By New Hormone Data

For many women, including the growing number who choose later-in-life pregnancy, predicting their biological clock’s relation to the timing of their menopause and infertility is critically important. Now, investigators from the University of Michigan have provided new information about hormonal biomarkers that can address the beginning of the menopause transition.

Erectile Dysfunction May Predict Heart Attacks

An expert has written an article on bmj.com that suggests a link between heart attacks and erectile dysfunction. Dr Geoffrey Hackett (Good Hope Hospital, Birmingham, UK) says that erectile dysfunction gives a two to three year early warning of a heart attack, but doctors are largely ignoring the relationship.

Depomed Initiates Second Phase 3 Trial In Menopausal Hot Flashes

Depomed, Inc. (NASDAQ:DEPO) announced today the enrollment and dosing of the first patient in Breeze 2, the second of two pivotal Phase 3 clinical trials in Depomed’s registration program for DM-5689 (formerly referred to as Gabapentin GRĀ®) for the treatment of menopausal hot flashes. Breeze 1, the first Phase 3 clinical trial, was initiated in September.

Danish Study Validates Combined Cyclical Hormone Replacement Therapy (HRT) With Monthly Menstrual Bleed

Wiley Systems, Inc. announced that a new Danish study featured in Europe’s leading cardiovascular journal suggests that women taking hormone replacement therapy (HRT) should cycle their hormones to have a menstrual bleed.

Exercise Keeps Your Brain From Deteriorating

According to research published ahead of print in the British Journal of Sports Medicine, brain power decline can be prevented and possibly even reversed by engaging in regular aerobic exercise.

Working Through The Menopause

Some women sail through it, others find it a challenge but few women like to talk openly about the menopause. With 70 per cent of women aged between 45 and 59 now in work, The University of Nottingham has been commissioned by the British Occupational Health Research Foundation to ask women, in total confidence, about their experience of working through the menopause. The menopause happens to all women, usually between the ages of 45 and 55.

Surgeons Find Sexual Dysfunction Is Common A Year After Major Trauma

Sexual dysfunction is prevalent long after physical injuries from major trauma have been treated and resolved. Nearly a third of patients who had sustained moderate to severe trauma reported some degree of sexual dysfunction, and most characterized the dysfunction as severe, a year after a traumatic event.

Vitamin K, Osteoporosis, And Postmenopausal Women

According to a new study published in the open-access journal PLoS Medicine, postmenopausal women with osteopenia did not prevent age-related bone mineral density (BMD) decline after taking a daily high dose supplement of vitamin K1. However, Angela Cheung (University of Toronto) and colleagues also found that vitamin K1 may offer protection against fracture and cancer in these women.

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